“Monolith Column” is another word for Kyoto Monotech . It is an evolutional column for liquid chromatography which breaks the common sense of column. It has been invented by Professor
(at the time) Naohiro Soga and Professor Kazuki Nakanishi (Kyoto University), and has been developed by Kyoto Monotech .
Technology
What's"Monolith Column"･･･?
"Monolith" means “integrated type”. Monolith column is different from the columns packed with the conventional porous spherical particle. It is an integrated type rod-shaped column for liquid
chromatography which contains two different sizes of the pores (mesopores, macropores).
Monolith column uses monolithic silica gel as a separation media.
| Conventional particle packed column |  | High separation BUT･･･ High-back pressure |
| Monolith Column（Integrated type） | >  | High separation AND→ Low back pressure!! |
When monolithic silica gel is used for a column of liquid chromatography,
analysis can be performed with
low-back pressure at high separation effeiciency. It also enables separation
of various materials such as DNA
and proteins by using a tabletop type small centrifuge or pipette in several
ten seconds.
In other words:
- You can control the mesopores and macropores and silica skeleton size independently.
- You can obtain high separation, low back pressure and easy operation at a same time.
- We will aim to simplify and cost reduction of the separation process.
| The stracture of monolithic silica gel … |
If you look at the cross section of monolithic silica gel with an SEM (electron microscope) image, you can see two types of pores: nanometer (nm) size (mesopores) and micrometer (μm) size (macropores).
